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There are several references in Greek mythology to a powerful drug that eliminated anguish and sorrow.

The immediate desired effects from consuming cannabis include relaxation and euphoria (the "high" or "stoned" feeling), a general alteration of conscious perception, increased awareness of sensation, increased libido and distortions in the perception of time and space.

At higher doses, effects can include altered body image, auditory and/or visual illusions, pseudohallucinations and ataxia from selective impairment of polysynaptic reflexes.

Evidence for causing these cancers is mixed concerning heavy, long-term use.

In general there are far lower risks of pulmonary complications for regular cannabis smokers when compared with those of tobacco.

The same review found that greater dose of marijuana and earlier age at onset of use were also associated with such alterations.A 2010 review found resting blood flow to be lower globally and in prefrontal areas of the brain in cannabis users, when compared to non-users.Because 97% of case-reports also smoked tobacco, a formal association with cannabis could not be made.If cannabis arteritis turns out to be a distinct clinical entity, it might be the consequence of vasoconstrictor activity observed from delta-8-THC and delta-9-THC.A 2015 analysis of six studies found little evidence that long-term or regular cannabis smoking was associated with lung cancer risk, though it could not rule out whether an association with heavy smoking exists.Cannabis is believed to be an aggravating factor in rare cases of arteritis, a serious condition that in some cases leads to amputation.In some cases, cannabis can lead to dissociative states such as depersonalization Aside from a subjective change in perception and mood, the most common short-term physical and neurological effects include increased heart rate, increased appetite and consumption of food, lowered blood pressure, impairment of short-term and working memory, psychomotor coordination, and concentration.