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Conversely, static exercise (such as weight-lifting) can cause the systolic pressure to rise significantly (during the exercise).

Studies have shown that since heart disease is the leading cause of death in women, regular exercise in aging women leads to healthier cardiovascular profiles.

Most beneficial effects of physical activity on cardiovascular disease mortality can be attained through moderate-intensity activity (40–60% of maximal oxygen uptake, depending on age).

Persons who modify their behavior after myocardial infarction to include regular exercise have improved rates of survival.

Persons who remain sedentary have the highest risk for all-cause and cardiovascular disease mortality.

There is clear evidence of exercise treatment efficacy for major depressive disorder and attention deficit hyperactivity disorder.

The American Academy of Neurology's clinical practice guideline for mild cognitive impairment indicates that clinicians should recommend regular exercise (two times per week) to individuals who have been diagnosed with this condition.

Although there have been hundreds of studies on physical exercise and the immune system, there is little direct evidence on its connection to illness.

Epidemiological evidence suggests that moderate exercise has a beneficial effect on the human immune system; an effect which is modeled in a J curve.

Physical exercise is important for maintaining physical fitness and can contribute to maintaining a healthy weight, regulating digestive health, building and maintaining healthy bone density, muscle strength, and joint mobility, promoting physiological well-being, reducing surgical risks, and strengthening the immune system.

Some studies indicate that exercise may increase life expectancy and the overall quality of life.